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Studies using stable isotope tracers suggest that an important characteristic of NAFLD patients is abnormally elevated DNL regardless of fasting

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In agreement with the expression profile of SP, it has been implicated in mood (Santarelli et al., 2001), stress (Papp et al., 2000), reward sensitivity (Thorsell et al., 2010), energy homeostasis (Karagiannides et al., 2008), pain (Hill, 2000), and learning (Huston and Hasenohrl, 1995)